Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
11016369 | Sensors and Actuators B: Chemical | 2019 | 25 Pages |
Abstract
We present the design and characterization of a monolithic complementary metal-oxide-semiconductor (CMOS) biosensor platform comprising of a switch-matrix-based array of 9â²216 carbon nanotube field-effect transistors (CNTFETs) and associated readout circuitry. The switch-matrix allows for flexible selection and simultaneous routing of 96 sensor elements to the corresponding readout channels. A low-noise, wide-bandwidth, wide-dynamic-range transimpedance continuous-time amplifier architecture has been implemented to facilitate resistance measurements in the range between 50âkΩ and 1âGΩ at a bandwidth of up to 1âMHz. The achieved accuracy of the resistance measurements over the whole range is 4%. The system has been successfully fabricated and tested and shows a noise performance equal to 2.14 pArms at a bandwidth of 1âkHz and 0.84ânArms at a bandwidth of 1âMHz. A batch integration of the CNTFETs has been achieved by using a dielectrophoresis (DEP)-based manipulation technique. The current-voltage curves of CNTFETs have been acquired, and the sensing capabilities of the system have been demonstrated by recording resistance changes of CNTFETs upon exposure to solutions with different pH values and different concentrations of NaCl. The smallest resolvable concentrations for the respective analytes were estimated to amount to 0.025 pH-units and 4âmM NaCl.
Related Topics
Physical Sciences and Engineering
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Authors
Alexandra Dudina, Florent Seichepine, Yihui Chen, Alexander Stettler, Andreas Hierlemann, Urs Frey,