| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 11022689 | Experimental and Molecular Pathology | 2018 | 65 Pages |
Abstract
In conclusion, liver cirrhosis is associated with deterioration of renal functions. Silymarin and Rvs have a potential hepatorenal therapeutic benefit through simultaneous enhancement of FXR/DDAH-1/eNOS pathway in both organs.
Keywords
ADMAPCNART PCRαSMAHSCsTGFβ1SMCsDDAH-1FXRGFRDDAHMODCRDALTHFDfarnesoid X receptorRVsα smooth muscle actinASTALKAlkaline phosphataseProliferating Cell Nuclear AntigenEndothelial dysfunctionchronic renal diseaseTransforming growth factor β1aspartate transaminaseOxidative stressintraperitonealasymmetric dimethylarginineRosuvastatinHigh fat dietSmooth muscle cellsHepatic stellate cellsendothelial nitric oxide synthaseCirrhosisSilymarinmean optical densityGlomerular filtration ratemapNitric oxidepolymerase chain reactionPCRKidney
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Authors
Yosra M. Magdy, Omnyah A. El-Kharashi, Dalia A.A. El-Waseef, Enas S. Nabih, Abeer A. Abd El Samad,