Curcumin and allopurinol ameliorate fructose-induced hepatic inflammation in rats via miR-200a-mediated TXNIP/NLRP3 inflammasome inhibition

Article ID	Journal	Published Year	Pages	File Type
11025706	Pharmacological Research	2018	45 Pages	PDF

Keywords

Allopurinol (PubChem CID: 2094)TXNIP NLRP3 NAFLD LDL-C ASC Nrf2 DCFH-DA 2′,7′-dichlorofluorescin diacetate keap1 O2−ROS nonalcoholic steatohepatitis Hepatic inflammation miR-200a Nonalcoholic fatty liver disease Triglycerides dihydroethidium Superoxide anion radical NF-E2-related factor 2 Fructose Fructose (PubChem CID: 5984)Nash DHE Thioredoxin interacting protein Kelch-like ECH-associated protein 1 total cholesterol Low-density lipoprotein cholesterol Curcumin Curcumin (PubChem CID: 969516)Reactive oxygen species

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Curcumin and allopurinol ameliorate fructose-induced hepatic inflammation in rats via miR-200a-mediated TXNIP/NLRP3 inflammasome inhibition

Authors

Xiao-Qing Ding, Wen-Yuan Wu, Rui-Qing Jiao, Ting-Ting Gu, Qiang Xu, Ying Pan, Ling-Dong Kong,