| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 11026017 | Prostaglandins & Other Lipid Mediators | 2018 | 17 Pages |
Abstract
Isolevuglandins are 4-ketoaldehydes formed by peroxidation of arachidonic acid. Isolevuglandins react rapidly with primary amines including the lysyl residues of proteins to form irreversible covalent modifications. This review highlights evidence for the potential role of isolevuglandin modification in the disease processes, especially atherosclerosis, and some of the tools including small molecule dicarbonyl scavengers utilized to assess their contributions to disease.
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Authors
Sean S. Davies, Linda S. May-Zhang,