Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
11029071 | Microbial Pathogenesis | 2018 | 21 Pages |
Abstract
Enterotoxigenic Escherichia coli (ETEC), as a universal pathogen, often causes diarrhea in animals and humans. However, whether ETEC infection induces apoptosis in host remains controversial. Herein, we use ETEC-infected piglet to investigate apoptosis in the jejunum. Apoptosis and the activation of capase-3 are observed in piglet jejunum after ETEC infection. Additionally, ETEC infection induces the activation of caspase-8 pathway, but inhibits the activation of caspase-9 pathway in piglet jejunum. These findings demonstrate that ETEC infection may inhibit the intrinsic pathway and activate the extrinsic pathway of apoptosis in piglets.
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Authors
Yaoyao Xia, Peng Bin, Shaojuan Liu, Shuai Chen, Jie Yin, Gang Liu, Zhiyi Tang, Wenkai Ren,