Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
11029081 | Microbial Pathogenesis | 2018 | 24 Pages |
Abstract
The antibacterial activity of sulfadiazine Au-PPh3, sulfadiazine Ph2P-Au-Au-PPh2, sulfamethoxazole Au-PPh3, sulfamethoxazole Ph2P-Au-Au-PPh2, sulfamethoxazole Au-PPh3 were tested against Pseudomonas aeruginosa. The antibacterial activity of sulfonamide was tested against P. aeruginosa through the MIC assay, quantitative analysis of biofilm inhibition and observation of biofilm formation with fluorescence microscopy. Besides, the compounds presented remarkable inhibition of P. aeruginosa biofilm formation. Furthermore, molecular docking was performed to identify the key structural features of these compounds with the binding site of the LasR receptor.
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Authors
Caren Rigon Mizdal, SÃlvio Terra Stefanello, Pablo Andrei Nogara, Félix Alexandre Antunes Soares, Lenice de Lourenço Marques, Marli Matiko Anraku de Campos,