Article ID Journal Published Year Pages File Type
1125912 Revista Portuguesa de Cardiologia 2015 7 Pages PDF
Abstract

IntroductionThe indiscriminate use of different diagnostic criteria for the definition of dyslipidemia may result in inaccurate interpretations, which could compromise diagnosis and therefore the therapeutic and prophylactic actions to be taken.ObjectiveTo analyze possible differences in prevalence rates of dyslipidemia in adolescents based on three diagnostic definitions.MethodsA cross-sectional study was conducted of a representative sample of Brazilian adolescents between 11 and 16 years of age. Blood samples were collected from 1000 students (423 boys and 577 girls) to determine fasting total cholesterol (TC), HDL and LDL cholesterol, and triglycerides (TG). The prevalence of dyslipidemia was established according to three definitions: those of the National Cholesterol Education Program (NCEP), the Brazilian Society of Cardiology (BSC), and the National Health and Nutrition Examination Survey (NHANES).ResultsSignificant differences (p<0.01) were found between the diagnostic criteria for TC (BSC 38.3%; NCEP 11.2%; NHANES 4.8%), HDL cholesterol (BSC 30.0%; NCEP 15.8% NHANES 18.4%), LDL cholesterol (BSC and NCEP 10.8% and NHANES 5.9%), and TG (BSC and NCEP 4.7% and NHANES 1.3%). The overall prevalence of dyslipidemia was 61% (BSC), 28.6% (NCEP) and 24.2% (NHANES). Agreement rates varied significantly (kappa 0.15–0.90).ConclusionsAlthough a high prevalence of dyslipidemia was observed in this study regardless of the diagnostic criteria used, the wide variation in rates highlights the need to establish a single definition with appropriate discriminatory power for adolescents.

ResumoFundamentoO uso indiscriminado de diferentes critérios diagnósticos para a determinação de dislipidemias pode resultar em interpretações imprecisas, podendo comprometer o diagnóstico e, consequentemente, as ações terapêuticas e profiláticas a serem empregadas.ObjetivoAnalisar possíveis diferenças nas taxas de prevalência de dislipidemias em adolescentes, com base em três critérios diagnósticos.MétodosEstudo transversal conduzido com uma amostra representativa de adolescentes brasileiros de 11 a 16 anos. Amostras de sangue foram coletadas de 1000 escolares (423 rapazes e 577 moças) para determinação do colesterol total (CT), HDL, LDL e triglicérides (TG) em jejum. A prevalência de dislipidemias foi estabelecida com base em três critérios diagnósticos: National Cholesterol Education Program (NCEP), Sociedade Brasileira de Cardiologia (SBC) e National Health and Nutrition Examination Survey (NHANES).ResultadosDiferenças significantes (p<0,01) foram identificadas entre os critérios diagnósticos analisados para CT (SBC=38,3%; NCEP=11,2%; NHANES=4,8%), HDL (SBC=30,0%; NCEP=15,8%; NHANES=18,4%), LDL (SBC/NCEP=10,8% e NHANES=5,9%) e TG (SBC/NCEP=4,7% e NHANES=1,3%). No geral, a prevalência de dislipidemias foi na ordem de 61% (SBC); 28,6% (NCEP) e 24,2% (NHANES). Os índices de concordância variaram amplamente (Kappa=0,15 a 0,90).ConclusõesEmbora uma elevada prevalência de dislipidemias tenha sido identificada neste estudo, independente dos critérios diagnósticos utilizados, a ampla variação nas taxas encontradas reforça a necessidade do estabelecimento de um critério único e com poder de discriminação adequado para adolescentes.

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