Optimization of maintenance therapy of Risperidone with CYP2D6 genetic polymorphisms through an extended translational framework-based prediction of target occupancies/clinical outcomes

Article ID	Journal	Published Year	Pages	File Type
11263539	Pharmacological Research	2018	47 Pages	PDF

Keywords

RCT mean prediction error Dopamine (PubChem CID: 681)visual predictive check Haloperidol (PubChem CID: 3559)MAPE VPC Serotonin (PubChem CID: 5202)POPPK P-gp CYP2D6 Risperidone (Pubchem CID: 5073)PANSS SAS MPE EPS Population pharmacokinetics P-glycoprotein Receptor occupancy Maintenance therapy Risperidone Extrapyramidal symptoms NONMEM pharmacodynamic pharmacokinetic confidence interval intermediate metabolizer extensive metabolizer poor metabolizer positive and negative syndrome scale

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Optimization of maintenance therapy of Risperidone with CYP2D6 genetic polymorphisms through an extended translational framework-based prediction of target occupancies/clinical outcomes

Authors

Han Qing Li, Jia Yin Xu, Yuan Yuan Gao, Liang Jin,