Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1148424 | Journal of Statistical Planning and Inference | 2008 | 22 Pages |
Abstract
We propose a new adaptive procedure for dose-finding in clinical trials with combination of two drugs when both efficacy and toxicity responses are available. We model the distribution of this bivariate binary endpoint using the bivariate probit model. The analytic formulae for the Fisher information matrix are obtained, that form the basis for derivation of the locally optimal, minimax, Bayesian, and adaptive designs in the framework of optimal design theory.
Keywords
Related Topics
Physical Sciences and Engineering
Mathematics
Applied Mathematics
Authors
Vladimir Dragalin, Valerii Fedorov, Yuehui Wu,