Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1149822 | Journal of Statistical Planning and Inference | 2008 | 7 Pages |
Abstract
We examine the issue of asymptotic efficiency of estimation for response adaptive designs of clinical trials, from which the collected data set contains a dependency structure. We establish the asymptotic lower bound of exponential rates for consistent estimators. Under certain regularity conditions, we show that the maximum likelihood estimator achieves the asymptotic lower bound for response adaptive trials with dichotomous responses. Furthermore, it is shown that the maximum likelihood estimator of the treatment effect is asymptotically efficient in the Bahadur sense for response adaptive clinical trials.
Related Topics
Physical Sciences and Engineering
Mathematics
Applied Mathematics
Authors
Yanqing Yi, Xikui Wang,