Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1150003 | Journal of Statistical Planning and Inference | 2008 | 9 Pages |
Abstract
In the paper we present a new method of calculating sampling intervals, so-called windows, allowing an experimenter some flexibility in timing the sample collection, while a minimum required design efficiency for parameter estimation is assured. The method is based on the Equivalence Theorem for D-optimality what makes the length of each window related to the parameter sensitivities. An example of calculating the windows in a pharmacokinetic study is presented. Some other methods of calculating efficient sampling windows are briefly discussed.
Keywords
Related Topics
Physical Sciences and Engineering
Mathematics
Applied Mathematics
Authors
B. Bogacka, P. Johnson, B. Jones, O. Volkov,