Recent advances in sample preparation techniques and methods of sulfonamides detection – A review

•An overview on recent trends in the sample preparation and determination of sulfonamides is given.•A comparison of different methods of real samples preparation is made.•The general chromatographic and other methods of SAs determination are discussed.•Examples of SAs determination in different matrices are given.

Sulfonamides (SAs) have been the most widely used antimicrobial drugs for more than 70 years, and their residues in foodstuffs and environmental samples pose serious health hazards. For this reason, sensitive and specific methods for the quantification of these compounds in numerous matrices have been developed. This review intends to provide an updated overview of the recent trends over the past five years in sample preparation techniques and methods for detecting SAs. Examples of the sample preparation techniques, including liquid–liquid and solid-phase extraction, dispersive liquid–liquid microextraction and QuEChERS, are given. Different methods of detecting the SAs present in food and feed and in environmental, pharmaceutical and biological samples are discussed.

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