Rapid and sensitive methodology for determination of ethyl carbamate in fortified wines using microextraction by packed sorbent and gas chromatography with mass spectrometric detection

- MEPS was first used to quantify ethyl carbamate in fortified wines.
- The extraction was optimized (DoE) to 300 μL of sample and 100 μL of dichloromethane.
- Good linearity (R2 = 0.9999) and low LOQ (4.5 μg L−1) were obtained.
- The method applicability was demonstrated by the analysis of 16 fortified wines.
- MEPS ensured efficiency and effectiveness without using sophisticated equipment.