| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1164658 | Analytica Chimica Acta | 2013 | 7 Pages |
•A new fluorescence probe for detection of Hg2+ ions was developed.•The probe can monitor Hg2+ ions in aqueous media and in blood in ppb level.•The probe facilitates naked-eye detection of Hg2+ ions.
The heavy metal mercury (Hg) is a threat to the health of people and wildlife in many environments. Among various chemical forms, Hg2+ salts are usually more toxic than their counterparts because of their greater solubility in water; thus, they are more readily absorbed from the gastrointestinal tract into circulation. Therefore, new chemical receptors for detecting Hg2+ ions in circulation are needed. In this study, we developed a rhodamine-based turn-on fluorescence probe to monitor Hg2+ in aqueous solution and in blood of mice with toxicosis. The chemodosimeter responds to Hg2+ ions stoichiometrically, rapidly, and irreversibly at room temperature as a result of a chemical reaction that produces strongly fluorescent oxadiazole. The new fluorescent probe shows good fluorescence response, with high sensitivity and selectivity, toward Hg2+ ions in aqueous solution and in blood from mice with toxicosis and facilitates the naked-eye detection of Hg2+ ions.
Graphical abstractA rhodamine-based turn-on fluorescence probe can monitor the blood Hg2+ ions in toxicosis mice with high sensitivity and selectivity, and facilitates naked-eye detection of Hg2+ ions.Figure optionsDownload full-size imageDownload as PowerPoint slide
