Analytical applications of the electrochemiluminescence of tris(2,2′-bipyridyl)ruthenium(II) coupled to capillary/microchip electrophoresis: A review

A comprehensive review on the development of analytical methods, by coupling electrochemiluminescence (ECL) detection with capillary electrophoresis (CE) and microchip electrophoresis (ME), is presented. After the description of the basic mechanism of ECL, the addition mode of luminescence reagent in CE–ECL system has been discussed. The analytical applications of the CE–ECL technique in terms of different analytes are also given. Due to the importance of ME as a separation method for the present and future, the ME detection methods based on ECL are considered in a relatively detailed way. Finally, possible trends for CE/ME-ECL in the near future are discussed.

Graphical abstractThe mechanism of Ru(bpy)32+ electrochemiluminescence, addition mode of Ru(bpy)32+, recent applications of capillary electrophoresis coupled with electrochemiluminescent detection in drug and other substrates analysis are reviewed.Figure optionsDownload full-size imageDownload as PowerPoint slide