| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1166359 | Analytica Chimica Acta | 2012 | 8 Pages |
Dissolved organic matter (DOM), present in many forms in water, can interfere with analysis of organic contaminants by atmospheric pressure ionization–mass spectrometry. A quantitative analysis of this interference, or matrix effect, on organic contaminant target analyte measurements was carried out using un-fractionated and fractionated dissolved natural organic matter from the Suwannee River, GA (SROM), a standard reference material, that was directly infused into the tandem mass spectrometer during multiple reaction monitoring (MRM) of a suite of endocrine disrupting compounds–pharmaceuticals and personal care products (EDC/PPCPs). Most target analytes suffered signal suppression in the presence of both fractionated and un-fractionated SROM, however greater interferences were measured with fractionated relative to bulk SROM. This finding is consistent with the view of organic matter as a supramolecular association of low molecular mass components having separate charged and structural features revealed only after dissociation.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Matrix effects on EDC/PPCPs analysis were quantified by post column DOM infusion. ► Matrix effects were distinguished between Suwannee River DOM and its fractions. ► A supramolecular association of DOM is interpreted with matrix effects measurements. ► The greatest interferences were produced by fractionated DOM.
