| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1166939 | Analytica Chimica Acta | 2011 | 6 Pages |
A highly selective and sensitive coumarin-based chemodosimeter 1 for Cu2+ in water is reported in this work. 1 was designed and facilely synthesized by a one-step reaction with coumarin as a fluorophore and 2-picolinic acid as the binding moiety, which showed very week fluorescence in buffer solution, and its fluorescence was considerably enhanced by the addition of Cu2+ at room temperature in 5 min. Mechanism study suggested that Cu2+ promoted the hydrolysis of 1 via the catalytic sensing cycle, generating a highly fluorescent product 7-hydroxycoumarin with fluorescence signal greatly amplified. The probe exhibited remarkably selective fluorescence enhancement to Cu2+ over other metal ions at 454 nm, with a detection limit of 35 nM Cu2+. Under optimal condition, 1 was successfully used for the determination of Cu2+ in fetal equine serum and two water samples.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights• A coumarin-based fluorescence turn on chemodosimeter for Cu2+ is facilely synthesized by a one-step reaction. • Cu2+ catalyzes the hydrolysis of chemodosimeter with fluorescence signal greatly amplified. • The chemodosimeter exhibits remarkably selective fluorescence enhancement to Cu2+ over other metal ions. • Detection of Cu2+ can be performed at room temperature with high sensitivity.
