Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1168389 | Analytica Chimica Acta | 2009 | 8 Pages |
Abstract
Biopartitioning micellar chromatography (BMC), a mode of micellar liquid chromatography that uses micellar mobile phases of Brij35 in adequate experimental conditions, has demonstrated to be useful in mimicking the drug partitioning process into biological systems. In this paper, the usefulness of BMC for predicting the partition coefficients from blood to lung, blood to liver, blood to fat and blood to skin is demonstrated. PLS2 and multiple linear regression (MLR) models based on BMC retention data are proposed and compared with other ones reported in bibliography. The proposed models present better or similar descriptive and predictive capability.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Y. Martín-Biosca, S. Torres-Cartas, R.M. Villanueva-Camañas, S. Sagrado, M.J. Medina-Hernández,