Article ID Journal Published Year Pages File Type
1168576 Analytica Chimica Acta 2009 5 Pages PDF
Abstract

Second-order advantage of excitation–emission fluorescence measurements was applied to the simultaneous determination of paracetamol (PC) and mefenamic acid (MF) in urine samples. Two drugs were quantified by multivariate curve resolution coupled to alternative least squares (MCR-ALS) in micellar media of sodium dodesyl sulfate (SDS). Experimental conditions including pH and SDS concentration were optimized. Under the optimum conditions, pH 2.0 and 0.05 mol L−1 of SDS, paracetamol and mefenamic acid were determined in concentration range 4.00–20.00 μg mL−1 and 0.80–5.00 μg mL−1, respectively, in urine samples.

Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
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