Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1169090 | Analytica Chimica Acta | 2008 | 9 Pages |
Abstract
The solution-phase sensor array of three cationic bis-boronic acid appended benzyl viologens (BBV) and the anionic fluorescent dye, 8-hydroxypyrene-1,3,6-trisulfonic acid trisodium salt (HPTS), is able to discriminate among five phospho sugars, four nucleotides and three neutral saccharides in aqueous buffered solution at low mM concentrations. Linear discriminant analysis, principal component analysis, and hierachical cluster analysis studies showed the “discrimination limit” (lowest analyte concentration where the discrimination is still 100%) to be 4 mM. Calculated Kb and Fmax/F0 values from binding curves of the three BBVs with 1–12 were also used to perform multi-variate analyses with very good discrimination results.
Related Topics
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Authors
Alexander Schiller, Boaz Vilozny, Ritchie A. Wessling, Bakthan Singaram,