Article ID Journal Published Year Pages File Type
1169114 Analytica Chimica Acta 2008 6 Pages PDF
Abstract
A novel and simple spectrophotometric method for the determination of Captopril with sodium 1,2-naphthoquinone-4-sulfonate is established in this paper. The detailed reaction mechanism is proposed and discussed. It is based on the fact that captopril can catalyze the reaction between sodium 1,2-naphthoquinone-4-sulfonate and hydroxyl ion to form 2-hydroxy-1,4-naphthoquinone in buffer solution of pH 13.00. Beer's law is obeyed in a range of 0.64-80 μg mL−1 at the maximal absorption wavelength of 442 nm. The equation of linear regression is A = 0.05815 + 0.00589C (μg mL−1), with a linear regression correlation coefficient of 0.9981. The detection limit is 0.3 μg mL−1, R.S.D. is 0.77% and the recovery rate is in range of 96.0-103.8%. Furthermore, the method has been validated and successfully applied to the determination of captopril in pharmaceutical samples.
Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
Authors
, , ,