Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1169114 | Analytica Chimica Acta | 2008 | 6 Pages |
Abstract
A novel and simple spectrophotometric method for the determination of Captopril with sodium 1,2-naphthoquinone-4-sulfonate is established in this paper. The detailed reaction mechanism is proposed and discussed. It is based on the fact that captopril can catalyze the reaction between sodium 1,2-naphthoquinone-4-sulfonate and hydroxyl ion to form 2-hydroxy-1,4-naphthoquinone in buffer solution of pH 13.00. Beer's law is obeyed in a range of 0.64-80 μg mLâ1 at the maximal absorption wavelength of 442 nm. The equation of linear regression is A = 0.05815 + 0.00589C (μg mLâ1), with a linear regression correlation coefficient of 0.9981. The detection limit is 0.3 μg mLâ1, R.S.D. is 0.77% and the recovery rate is in range of 96.0-103.8%. Furthermore, the method has been validated and successfully applied to the determination of captopril in pharmaceutical samples.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Linxiao Gao, Lingli Wu, Quanmin Li,