Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1171678 | Analytica Chimica Acta | 2006 | 4 Pages |
Abstract
Nanogap-impedance biosensors with electrode separations of 75 nm have been fabricated by means of standard optical lithography and a sacrificial layer technique. Due to a large surface-to-volume ratio and high sensitivity, these sensors are superior compared to open interdigitated electrode structures. As a model, the blood coagulation factor thrombin was detected. As specific receptors, either an antibody or a RNA-aptamer have been used. The microwave frequency impedance measurements showed that both ligands were equally suitable for the specific detection of thrombin.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
U. Schlecht, A. Malavé, T. Gronewold, M. Tewes, M. Löhndorf,