Simultaneous profiling analysis of alkylphenols and amines by gas chromatography and gas chromatography–mass spectrometry

Two-phase O-ethoxycarbonylation was performed to alkylphenols in acidic solution with ethyl chloroformate present in dichloromethane phase fortified with triethylamine with subsequent N-ethoxycarbonylation of amines after adjusting to alkaline pH. The resulting ethoxycarbonyl derivatives were subjected to pentafluoropropionylation, clean-up and concentration for analysis by gas chromatography and gas chromatography–mass spectrometry. The present method was linear (r ≥ 0.9959) in the range of 0.5–10.0 μg ml−l with good precision (≤9.5%) and accuracy (−8.9 to 9.5%) for 20 phenols and 27 amines examined, allowing simultaneous screening for a total of one alkylphenol and four amines from wine and beer.