Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
12067 | Biomaterials | 2005 | 8 Pages |
Abstract
The use of three-dimensional scaffolds in cell and tissue engineering is widespread; however, the use of such scaffolds, which bear additional cellular cues such as nanotopography, is as yet in its infancy. This paper details the novel fabrication of nylon tubes bearing nanotopography via polymer demixing, and reports that the topography greatly influenced fibroblast adhesion, spreading, morphology and cytoskeletal organisation. The use of such frameworks that convey both the correct mechanical support for tissue formation and stimulate cells through topographical cues may pave the way for future production of intelligent materials and scaffolds.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Catherine Cecilia Berry, Matthew J Dalby, David McCloy, Stanley Affrossman,