Solid-core and hollow magnetic nanostructures: Synthesis, surface modifications and biological applications

In the need of development of versatile and flexible platforms for sensing, nanostructured particles are one of the systems of choice. Additionally, the state-of-the-art, controlled surface modifications of these structures offer broad possibilities of using such systems for diagnostics and therapy, often referred to as thera(g)nostics. In this brief review we will focus on the synthesis and surface modifications of solid-core magnetic nanostructures and polymeric capsules containing nanoferrites modified with anti-cancer drug — doxorubicin, designed for magnetic field-driven drug delivery for cancer therapy. We will also outline some problems related to the usage of such structures. The encapsulation and distribution of magnetic iron oxide nanoparticles modified with doxorubicin will be demonstrated in the polypyrrole spherical microvessels.

► Surface modification of magnetic nanoparticles as carriers for drug delivery ► Interactions of doxorubicin with DMPC monolayer. ► Magnetic nanoparticles modified with doxorubicin. ► Magnetic field effect on the intercalation of doxorubicin attached to the nanoferrites into dsDNA. ► Encapsulation of nanoferrites modified with doxorubicin into the polymeric microvessels.