Synthesis, spectral characterization and in vitro microbiological evaluation of novel glyoxal, biacetyl and benzil bis-hydrazone macrocyclic Schiff bases and their Co(II), Ni(II) and Cu(II) complexes

A series of binuclear Co(II), Ni(II) and Cu(II) complexes were synthesized by the template condensation of glyoxal, biacetyl or benzil bis-hydrazide, 2,6-diformyl-4-methylphenol and Co(II), Ni(II) or Cu(II) chloride in a 2:2:2 M ratio in ethanol. These 22-membered macrocyclic complexes were characterized by elemental analyses, magnetic, molar conductance, spectral, thermal and fluorescence studies. Elemental analyses suggest the complexes have a 2:1 stoichiometry of the type [M2LX2]·nH2O and [Ni2LX22H2O]·nH2O (where M = Co(II) and Cu(II); L = H2L1, H2L2 and H2L3; X = Cl; n = 2). From the spectroscopic and magnetic studies, it has been concluded that the Co(II) and Cu(II) complexes display a five coordinated square pyramidal geometry and the Ni(II) complexes have a six coordinated octahedral geometry. The Schiff bases and their metal complexes have also been screened for their antibacterial and antifungal activities by the MIC method.

Graphical abstractA series of glyoxal, biacetyl and benzil macrocyclic bis-hydrazone derivatives have been synthesized and characterized by spectral magnetic and thermal data, and have been screened for their antibacterial and antifungal activity by the MIC method.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Synthesis of glyoxal, biacetyl and benzil bis-hydrazones. ► Synthesis and characterization Co(II), Ni(II) and Cu(II) complexes with bis-hydrazones. ► Antibacterial and antifungal studies showing good results.