Conjugates of platinum nanoparticles with gallium tetra – (4-Carboxyphenyl) porphyrin and their use in photodynamic antimicrobial chemotherapy when in solution or embedded in electrospun fiber

The conjugation of Pt nanoparticles with ClGa(III) 5,10,15,20-tetrakis-(4-carboxyphenyl) porphyrin (ClGaTCPP) showed greater antimicrobial activity against a gram positive and drug resistant bacteria Staphylococcus aureus, than when the porphyrin was used alone. ClGaTCPP and its conjugate with platinum nanoparticle was successfully electrospun into a polystyrene polymer where the diameter ranged from 10 to 22 μm. The conjugates within the fiber still showed activity towards S. aureus.

Graphical abstractThe conjugation of Pt nanoparticles with ClGa(III) 5,10,15,20-tetrakis-(4-carboxyphenyl) porphyrin showed greater antimicrobial activity against Staphylococcus aureus, than when the nanoparticles or the porphyrins are used separately and when electrospun into fibers.Figure optionsDownload full-size imageDownload as PowerPoint slide