Synthesis, structure and properties of ruthenium(II) complexes with quinolinedione derivatives as chelate ligands: Crystal structure of [Ru(CO)2Cl2(6-methoxybenzo[g]quinoline-5,10-dione)]

The reaction of the dimer complex [{Ru(CO)3Cl2}2] with the ligands 4,6-dichloroquinoline-5,8-dione and 6-methoxybenzo[g]quinoline-5,10-dione in ethanol solution led to the neutral mononuclear complexes of general formula [Ru(CO)2Cl2(κ2-quinolinedione-N,O)]. The complexes were characterized by elemental analysis, IR and RMN spectroscopy, and the molecular structure of [Ru(CO)2Cl2(6-methoxybenzo[g]quinoline-5,10-dione)] was determined by single-crystal X-ray diffraction. The redox chemistry of ligands and complexes was investigated by cyclic voltammetry, and their potential antitumor activity was also evaluated.

Graphical abstractThe reaction of complex [{Ru(CO)3Cl2}2] with substituted quinolinediones in ethanol yield mononuclear complexes of the type [Ru(CO)Cl2(κ2-quinolinedione-N,O)]. The molecular structure of complex [Ru(CO)2Cl2(6-methoxybenzo[g]quinoline-5,10-dione)] has been determined by single-crystal X-ray diffraction. The redox chemistry of ligands and complexes was investigated by cyclic voltammetry. The potential antitumor activities of free ligands and the ruthenium complexes are also evaluated.Figure optionsDownload full-size imageDownload as PowerPoint slide