| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1336159 | Polyhedron | 2011 | 9 Pages |
Three new complexes of Ru(II), namely [RuCl2(Glun-N,O)2]Na2 (I; Glun = glucosaminate), [RuCl2(1-Tglu)(EtOH)2]Na (II; 1-Tglu = 1-thio-β-d-glucose) and [Ru2(EtOH)6(AL)Cl4] (III; AL = 6′-aminolactose) were prepared from the same Ru(II) precursor, [RuCl2(DMSO)4] (DMSO = dimethyl sulfoxide). The characterization of the complexes was carried out by elemental analysis, FT-IR, ES-MS, NMR, EXAFS and DFT calculations. The effectiveness of the complexes on metastatic melanoma A 375 was investigated. The results show that complex II is the most active species.
Graphical abstractThree new complexes of Ru(II) were prepared from the same Ru(II) precursor, [RuCl2(DMSO)4]. The characterization of the complexes was carried out by elemental analysis, FT-IR, ESI-MS, NMR, EXAFS and DFT calculations. The effectiveness of the complexes on the metastatic melanoma A375 was investigated. One complex was a considerably more active species.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► In this research we synthesized and characterized three new ruthenium complexes with carbohydrates. ► Amino- and thio-derivatives of some natural sugars were employed as new ligands. ► Data concerning the antiproliferative and antinvasive activity of the new compounds were collected.
