Anagostic interactions, revisiting the crystal structure of nickel dithiocarbamate complex and its antibacterial and antifungal studies

The synthesis of Ni(dtc)2 [dtc = diethyldithiocarbamate] has been achieved by the interaction of NiL(ClO4)2 with sodium diethyldithiocarbamate. Although single crystal structure of this complex was already reported (R = 10.6%), we were able to refine crystal structure up to R = 2.99%. We also observed rare C–H⋯Ni anagostic interactions generally exhibited by d8 complexes which were overlooked previously. To investigate the structure of Ni(dtc)2 in solution, variable temperature NMR spectra in solution have also been recorded between 25 and −50 °C. Ni(dtc)2 was also tested for antibacterial and antifungal activities. It showed higher activity against the bacteria and fungi than the known antibiotics.

Graphical abstractThe synthesis of Ni(dtc)2 [dtc = diethyldithiocarbamate] has been achieved by the interaction of NiL(ClO4)2 with sodium diethyldithiocarbamate. Rare C–H⋯Ni anagostic interactions generally exhibited by d8 complexes have been explored, which were overlooked previously. Ni(dtc)2 was also tested for antibacterial and antifungal activities and found to be highly effective against the bacteria and fungi than the known antibiotics.Figure optionsDownload full-size imageDownload as PowerPoint slide