μ-Oxamido binuclear copper (II) complexes: Synthesis, crystal structure, DNA interaction and antibacterial studies

Four binuclear copper (II) complexes [Cu(oxpn)Cu(B)]2+ (2–5) bridged by N, N′-bis[3-(methylamino) propyl] oxamide (oxpn), where, B is N, N-donor heterocyclic bases (viz. 2,2′-bipyridine (bpy, 2), 1,10-phenathroline (phen, 3), dipyrido[3,2-d:2′,3′-f]quinoxaline (dpq, 4) and dipyrido[3,2-a:2′,3′-c]phenazine (dppz, 5) are synthesized, characterized by different spectroscopic and single crystal X-ray data technique. The phen (3) and dpq (4) complexes were structurally characterized by X-ray data analysis. Their DNA binding, oxidative cleavage and antibactirial activities were studied. The dpq (4) and dppz (5) complexes are avid binders to the Calf thymus DNA (CT-DNA). The phen (3), dpq (4) and dppz (5) complexes show efficient oxidative cleavage of supercoiled DNA (SC DNA) through hydroxyl radical (OH) pathway in the presence of Mercaptopropionic acid (MPA).

Graphical abstractBinuclear copper (II) complexes [Cu(oxpn)Cu(B)]2+ (2–5) bridged by N, N′ bis[3-(methylamino) propyl] oxamide (oxpn), where, B is 2,2′-bipyridine(bpy,2), 1,10-phenathroline(phen,3), dipyrido[3,2-d:2′,3′-f]quinoxaline(dpq,4) and dipyrido[3,2-a:2′,3′-c]phenazine (dppz,5) are synthesize, characterized, their DNA binding, oxidative cleavage, antibactirial activities were studied The complexes 4 and 5 were characterized by X-ray data. The dpq, dppz complexes are avid binders to the CT-DNA, show efficient oxidative cleavage of SC-DNA involving OH species.Figure optionsDownload full-size imageDownload as PowerPoint slide