Synthesis, crystal structures, antimicrobial, antifungal and antituberculosis activities of mixed ligand silver(I) complexes

The biological activity of some new mixed silver–phosphane–thio-ligand complexes, with 1:1:2, 1:1:1 and 1:2:1 (Ag:phospine:ligand) compositions, have been examined. Ten compounds were prepared using a series of silver(I) salts [AgX, where X = NO3, ClO4, PF6 and Br], tertiary phosphines and the ligands thiosemicarbazide, 2-(propan-2-ylidene)hydrazinecarbothioamide, and thiazolidine-2-thione. The syntheses were carried out under ambient conditions, and the ten complexes obtained were found to be light stable. All 10 compounds were characterized by elemental analysis, FTIR, and NMR spectroscopy, whereas nine compounds were characterized by X-ray diffraction analysis. The anti-proliferative activities were evaluated by minimum inhibitory concentration (MIC: μg/mL) in an aqueous suspension system and they all show promising potential activity against selective strains of Gram-positive and Gram-negative bacteria, fungous and Mycrobaterium tuberculosis H37Rv.

Graphical abstractSilver(I) mixed ligand mononuclear and binuclear bridging complexes have shown interesting anti-proliferative activity against different strains of Gram+ and Gram− bacteria, one strain of fungous as well as Mycrobaterium tuberculosis H37Rv.Figure optionsDownload full-size imageDownload as PowerPoint slide