| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1337552 | Polyhedron | 2009 | 5 Pages |
2,6-Diacetylpyridine bis(benzenesulfonohydrazide) Schiff bases (L1, L2 and L3) and their Cu(II) complexes of the general formula [CuL·H2O] were synthesized and characterized by various spectroscopic techniques. The crystal structure of [CuL3·(py)]·py was investigated by single crystal X-ray structure analysis. The Cu(II) cation has near square pyramidal, penta-coordinate geometry. The binegatively charged tetradentate Schiff base is asymmetrically coordinated to the Cu(II) ion via the pyridine N atom, the azomethine N atom, the sulfonyl O atom and the deprotonated hydrazine N atom. There is a pyridine molecule apically coordinated to the Cu(II) ion. All the Schiff bases and their copper(II) complexes were screened by the disc diffusion method against multi-drug resistant (MDR) gram-negative and gram-positive bacteria. The minimum inhibitory concentration (MIC) values were also determined. These results show that the antibacterial activity of the Schiff bases against Methicillin-resistant Staphylococcus aureus (MRSA) is enhanced when they are chelated with the copper(II) ion.
Graphical abstractX-ray crystallographic analysis on [CuL3·(py)]·py shows that the complex has a near square pyramidal, penta-coordinate geometry. The binegatively charged tetradentate Schiff base is asymmetrically coordinated to the Cu(II) ion via the pyridine N, the azomethine N, the sulfonyl O and the hydrazine N. A pyridine molecule is apically coordinated to the Cu(II) ion.Figure optionsDownload full-size imageDownload as PowerPoint slide
