| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1337688 | Polyhedron | 2012 | 6 Pages |
Complexes [Cu(2AcPh)Cl]·2H2O (1), [Cu(2AcpClPh)Cl]·2H2O (2), [Cu(2AcpNO2Ph)Cl] (3), [Cu(2BzPh)Cl] (4). [Cu(2BzpClPh)Cl] (5) and [Cu(2BzpNO2Ph)Cl] (6) were obtained with 2-acetylpyridine-phenylhydrazone (H2AcPh), 2-acetylpyridine-para-chloro-phenylhydrazone (H2AcpClPh), 2-acetylpyridine-para-nitro-phenylhydrazone (H2AcpNO2Ph), 2-benzoylpyridine-phenylhydrazone (H2BzPh), 2-benzoylpyridine-para-chloro-phenylhydrazone (H2BzpClPh) and 2-benzoylpyridine-para-nitro-phenylhydrazone (H2BzpNO2Ph). The hydrazones showed poor antibacterial effect against Staphylococcus aureus, Enterococcus faecalis and Pseudomonas aeruginosa but demonstrated significant antifungal activity against Candida albicans. Upon coordination to copper(II) the antibacterial and antifungal activities appreciably increased. H2AcpClPh, H2BzpClPh and their copper(II) complexes (2) and (5), respectively, were as active as fluconazole against C. albicans.
Graphical abstract[Cu(2AcPh)Cl]·2H2O (1), [Cu(2AcpClPh)Cl]·2H2O (2), [Cu(2AcpNO2Ph)Cl] (3), [Cu(2BzPh)Cl] (4). [Cu(2BzpClPh)Cl] (5) and [Cu(2BzpNO2Ph)Cl] (6) were obtained with 2-acetylpyridine-phenylhydrazone (H2AcPh), 2-acetylpyridine-para-chloro-phenylhydrazone (H2AcpClPh), 2-acetylpyridine-para-nitro-phenylhydrazone (H2AcpNO2Ph), and the corresponding 2-benzoylpyridine-derivatives (H2BzPh, H2BzpClPh, H2BzpNO2Ph). Upon coordination to copper(II) the antimicrobial activities appreciably increased. H2AcpClPh, H2BzpClPh and complexes (2) and (5) were as active as fluconazole against Candida albicans.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Copper(II) complexes were obtained with pyridine-derived hydrazones. ► Hydrazones showed poor antibacterial activity. ► Hydrazones presented significant antifungal activity against Candida albicans. ► Upon coordination to copper(II) the antimicrobial activities appreciably increased. ► Some of the studied compounds were as active as fluconazole against C. albicans.
