Electron-deficient [TiIV(salophen)(OTf)2]: A new and highly efficient catalyst for the acetylation of alcohols and phenols with acetic anhydride

In the present work, a highly efficient method for acetylation of alcohols and phenols with acetic anhydride catalyzed by high-valent [TiIV(salophen)(OTf)2] is reported. Under these conditions, primary, secondary and tertiary alcohols as well as phenols were acetylated with short reaction times and high yields. The catalyst was reused several times without loss of its catalytic activity.

Graphical abstractA highly efficient method for the acetylation of alcohols and phenols with acetic anhydride catalyzed by high-valent [TiIV(salophen)(OTf)2] is reported. Under these conditions, primary, secondary and tertiary alcohols as well as phenols were acetylated with short reaction times and in high yields. The catalyst was reused several times without loss of its catalytic activity.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Electron-deficient Ti(IV)salophen was used as a catalyst. ► The corresponding acetates were obtained by the reaction of alcohols and phenols with acetic anhydride. ► The reaction was carried out at room temperature. ► The catalyst was reusable.