| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1338584 | Polyhedron | 2013 | 7 Pages |
The reactions of iminophosphine ligands with [PtCl2(COD)], [PtCl2(DMSO)2], and [Au(tht)Cl] has been investigated. The new platinum(II) and gold(I) complexes were characterised using elemental analysis, electrospray ionisation-mass spectrometry (ESI-MS), NMR (1H and 31P) and IR spectroscopy and X-ray diffraction studies. In vitro cytotoxic study results show that platinum and gold complexes block the proliferation of WHCO1 and KYSE450 cell lines with an IC50 range of 2.16–9.47 μM.
Graphical abstractNovel platinum(II) and gold(I) complexes have been synthesised and fully characterised by conventional means. The complexes were then evaluated for their anticancer activity against WHCO1 and KYSE450 cell lines.Figure optionsDownload full-size imageDownload as PowerPoint slide
