Highly regioselective conversion of epoxides to β-hydroxy nitriles using metal(II) Schiff base complexes as new catalysts under mild conditions

Epoxides undergo efficient ring opening with potassium cyanide in acetonitrile in the presence of metal Schiff base complexes as catalysts. This method was carried out under neutral and mild conditions with both high yields and high regioselectivity within a short period of time. Thus, several β-hydroxy nitriles, useful intermediates for the synthesis of biologically active molecules, were easily obtained at room temperature.

Graphical abstractIn this research, ring opening of epoxides with potassium cyanide in the presence of metal Schiff base complexes as new catalysts under neutral and mild conditions is described. With this protocol, β-hydroxy nitriles were obtained in high yields and high regioselectivity within a short period of time.Figure optionsDownload full-size imageDownload as PowerPoint slide