Article ID Journal Published Year Pages File Type
1339149 Polyhedron 2008 5 Pages PDF
Abstract

S-Benzyl-β-N-(benzoyl) dithiocarbazate (SBNBODTC) a new disubstituted dithio-carbazate oxygen–sulfur (OS) donor ligand derived from reaction of S-benzyl dithiocarbazate with benzoyl chloride, formed bis-chelated complexes of general formula [M(OS)2] where M is Cu2+, Ni2+, Cd2+, Co2+ or Pb2+ and OS is a uninegative bidentate ligand. The ligand and its metal complexes have been characterized by a variety of physico-chemical techniques. S-benzyl-β-N-(benzoyl) dithiocarbazate crystallized with Z′ = 2 in its thione form in cis–cis conformation, with the N–N bond adopting a cis geometry with respect to CS, while the S-benzyl group adopts a cis geometry with respect to the thione sulfur atom across the C–S bond. SBNBODTC, Cu(OS)2, Ni(OS)2 and Pb(OS)2 display marked cytotoxicity against HL-60 (human myeloid leukemia) while Cd(OS)2 and Co(OS)2 are moderately cytotoxic. The compounds showed moderate but selective activity towards targeted pathogens.

Graphical abstractS-Benzyl-β-N-(benzoyl) dithiocarbazate (SBNBODTC) a new disubstituted dithio-carbazate oxygen–sulfur (OS) donor ligand derived from reaction of S-benzyl dithiocarbazate with benzoyl chloride, formed bis-chelated complexes of general formula [M(OS)2] where M is Cu2+, Ni2+, Cd2+, Co2+ or Pb2+ and OS is a uninegative bidentate ligand. The ligand and its metal complexes have been characterized by a variety of physico-chemical techniques. S-Benzyl-β-N-(benzoyl) dithiocarbazate crystallized with Z′ = 2 in its thione form in cis–cis conformation, with the N–N bond adopting a cis geometry with respect to CS, while the S-benzyl group adopts a cis geometry with respect to the thione sulfur atom across the C–S bond. SBNBODTC, Cu(OS)2, Ni(OS)2 and Pb(OS)2 display marked cytotoxicity against HL-60 (human myeloid leukemia) while Cd(OS)2 and Co(OS)2 are moderately cytotoxic. The compounds showed moderate but selective activity towards targeted pathogens.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Inorganic Chemistry
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