Structural characterization and cytotoxicity studies of ruthenium(II)–dmso–chloro complexes of chalcone and flavone derivatives

A synthetic precursor cis-[RuIICl2(dmso)4] is complexed separately with 3-(4-benzyloxyphenyl)-1-(2-hydroxylphenyl)-prop-2-en-1-one (L1H) and 2-(4-benzyloxyphenyl)-3hydroxy-chromen-4-one (L2H). The resulting complexes are assigned the composition fac-[RuCl(S-dmso)3(L1)] 1 and fac-[RuCl(S-dmso)3(L2)] 2 using elemental analyses, FAB mass data and spectroscopic (IR, 1H NMR, UV–Vis, emission) spectral properties. The X-ray diffraction analysis shows that complexes self-associate through non-covalent interactions and provide 1D and 2D supramolecular structures. These complexes are assayed for their cytotoxicity studies on Dalton Lymphoma cell lines.

Graphical abstractBiologically relevant chalcone and flavone derivatives are complexed with cis-[RuCl2(dmso)4] giving two complexes of the general formula fac-[RuCl(S-dmso)3(L1/L2)] characterized by spectroscopic and X-ray diffraction techniques. These complexes are screened for their antitumor properties against Dalton Lymphoma cell lines.Figure optionsDownload full-size imageDownload as PowerPoint slide