Article ID Journal Published Year Pages File Type
1339374 Polyhedron 2008 5 Pages PDF
Abstract

Four new compounds, [Me4N]4H5[(RGe)3(XW9O34−n)2] (R = HOOCCH2CH2, HOOCCH2(m-NO2C6H4)CH, X = P, n = 0; X = Sb, n = 1) have been prepared from trichlorogermanium precursors and lacunary polyoxometallates ([PW9O34]9− and [SbW9O33]9−). The products were characterized by means of elemental analysis, IR spectroscopy, 1H NMR and 183W NMR spectroscopy. 183W NMR spectra of the complexes support the stoichiometry of the new heteropolyanions and the probable retention of the XW9 units in water. The organogermanium substituted complexes showed promising activity against two human tumor cell lines (leucocythemia Hela cells and S180 cells) in vitro and [Me4N]4H5[(HOOCCH2CH2Ge)3(SbW9O33)2] exhibited some certain antitumoral activity in vivo and can increase the immune ability of the spleen.

Graphical abstractFour new compounds, [Me4N]4H5[(RGe)3(XW9O34−n)2] (R = HOOCCH2CH2, HOOCCH2(m-NO2C6H4)CH, X = P, n = 0; X = Sb, n = 1) have been prepared from trichlorogermanium precursors and lacunary polyoxometallates ([PW9O34]9− and [SbW9O33]9−). The products were characterized by means of elemental analysis, IR spectroscopy, 1H NMR and 183W NMR spectroscopy. 183W NMR spectra of the complexes support the stoichiometry of the new heteropolyanions and the probable retention of the XW9 units in water. The organogermanium substituted complexes showed promising activity against two human tumor cell lines (leucocythemia Hela cells and S180 cells) in vitro and [Me4N]4H5[(HOOCCH2CH2Ge)3(SbW9O33)2] exhibited some certain antitumoral activity in vivo and can increase the immune ability of the spleen.Figure optionsDownload full-size imageDownload as PowerPoint slide

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Physical Sciences and Engineering Chemistry Inorganic Chemistry
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