| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1339634 | Polyhedron | 2008 | 5 Pages |
The iron(III) complexes [Fe(2Am4DH)2]Cl (1), [Fe(2Am4Me)2]Cl (2) and [Fe(2Am4Et)2]Cl (3) with 2-pyridineformamide thiosemicarbazone (H2Am4DH) and its N(4)-methyl (H2Am4Me) and N(4)-ethyl (H2Am4Et) derivatives were obtained and characterized by means microanalyses, infrared and EPR spectra. The electrochemical behavior of the complexes was investigated. The thiosemicarbazones and complexes (1) and (2) presented toxicity against Artemia salina at low concentrations. Since this bioassay has a good correlation with cytotoxic activity in human solid tumors, the studied compounds present potential pharmacological applications.
Graphical abstractThe iron(III) complexes [Fe(2Am4DH)2]Cl (1), [Fe(2Am4Me)2]Cl (2) and [Fe(2Am4Et)2]Cl (3) with 2-pyridineformamide thiosemicarbazone (H2Am4DH) and its N(4)-methyl (H2Am4Me) and N(4)-ethyl (H2Am4Et) derivatives were obtained. The thiosemicarbazones and complexes 1 and 2 presented toxicity against Artemia salina at low concentrations, suggesting that the studied compounds might present antineoplastic activity. CompoundLD50* μmol L−1 ± SD against Artemia salinaH2Am4DH35.24 ± 7.11[Fe(2Am4DH)2]Cl (1)30.14 ± 1.93H2Am4Me26.09 ± 3.96[Fe(2Am4Me)2]Cl (2)14.12 ± 0.98H2Am4Et31.89 ± 3.38[Fe(2Am4Et)2]Cl (3)>90Full-size tableTable optionsView in workspaceDownload as CSV
