| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1340756 | Polyhedron | 2007 | 5 Pages |
The entrapped [Ru(terpy)(L)NO](PF6)3, where terpy = 2,2′:6′,2″-terpyridine and L = 2,2′-bipyridine (bpy) and 3,4-diiminebenzoic acid (NH · NHq) complexes into sol–gel processed polysiloxane and silicone matrices, shows NO release characteristics when submitted to light irradiation at 355 and 532 nm, as judged by NO measurement using a NO-sensor electrode. The pharmacological properties of doped matrix showed vasodilator characteristics by visible light irradiation, which is of great interest because the target delivery system can avoid the occurrence of side effects possibly by the aquo ruthenium species. All matrices obtained showed to be amorphous materials. The scanning electron micrographs of the matrices showed irregularly shaped particles, with a broad size of 1000 μm for both matrices and homogeneous distribution.
Graphical abstractThe entrapped [Ru(terpy)(L)NO](PF6)3, terpy = 2,2′:6′,2″-terpyridine and L = 2,2′-bipyridine (bpy) and 3,4-diiminebenzoic acid (NH · NHq), complexes into sol–gel and silicone matrices, shows NO release characteristics when submitted to light irradiation. The pharmacological properties of doped matrix showed vasodilator characteristics due to NO release.Figure optionsDownload full-size imageDownload as PowerPoint slide
