The bonding of ribavirin to platinum(II) ion.: The X-ray and spectroscopy of Pt(II) complexes with 1-β-d-ribofuranosyl-1,2,4-triazole-3-carboxamide and dimethylsulfoxide

A platinum(II) complex with 1-β-d-ribofuranosyl-1,2,4-triazole-3-carboxamide is obtained and characterised spectroscopically with 1H, 13C, 15N, 195Pt NMR and IR. Significant 15N NMR coordination shifts (−92.7 and +18.4 ppm) were observed, respectively for N(4) and N(7) indicating these nitrogen atoms as a metallation sites. The X-ray crystal structures of two hydrates [PtCl(dmso)(N4N7-rib)]·H2O (1) and [PtCl(dmso)(N4N7-rib)]·2H2O (2) have been solved. Both complexes revealed square-planar coordination geometry for the Pt atoms with chelate ribavirin, S-bonded dimethylsulfoxide and chloride anion, the distances being as follows: PtN(4) 2.009(4), PtN(7) 2.041(4), PtS 2.218(1), PtCl 2.304(1) Å for 1 and PtN(4) 2.032(7), PtN(7) 2.028(7), PtS 2.212(2), PtCl 2.290(2) Å for 2.

The X-ray crystal structures of two platinum(II) hydrates with 1-β-d-ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin) have been solved. Both complexes revealed square-planar coordination geometry for Pt atoms with chelate ribavirin (N4,N7), S-bonded dimethylsulfoxide and chloride anion. Significant 15N NMR coordination shifts (−92.7 and +18.4 ppm) were observed, respectively for N(4) and N(7) atoms indicating these nitrogen atoms as metallation sites.Figure optionsDownload full-size imageDownload as PowerPoint slide