Structural refinement of pyrazolo[4,3-d]pyrimidine derivatives to obtain highly potent and selective antagonists for the human A3 adenosine receptor

Article ID	Journal	Published Year	Pages	File Type
1393840	European Journal of Medicinal Chemistry	2016	17 Pages	PDF

Keywords

DPCPX NECA Cl-IB-MECA EL2 I-AB-MECA 8-cyclopentyl-1,3-dipropyl-xanthine cAMP G-protein-coupled receptors Cyclic adenosine monophosphate Adenosine receptor antagonists Second extracellular loop transmembrane Molecular Operating Environment MOE Pyrazolopyrimidines Adenosine receptor

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

Preview

Structural refinement of pyrazolo[4,3-d]pyrimidine derivatives to obtain highly potent and selective antagonists for the human A3 adenosine receptor

Authors

Lucia Squarcialupi, Daniela Catarzi, Flavia Varano, Marco Betti, Matteo Falsini, Fabrizio Vincenzi, Annalisa Ravani, Antonella Ciancetta, Katia Varani, Stefano Moro, Vittoria Colotta,