Synthesis and antimicrobial activity of new 1-alkyl/cyclohexyl-3,3-diaryl-1′-methylspiro[azetidine-2,3′-indoline]-2′,4-diones

The paper describes the synthesis of new 1-alkyl/cyclohexyl-3,3-diaryl-1′-methylspiro[azetidine-2,3′-indoline]-2′,4-diones from the reactions of the 2-diazo-1,2-diarylethanones with 1-methyl-3-(alkyl/cyclohexylimino)indolin-2-ones under thermal condition. The compounds, characterized by satisfactory analytical and spectral (IR, 1H NMR and 13C NMR) data, have been screened for their antibacterial and antifungal activities.

Graphical abstractA series of 10 new spiro[azetidine-2,3′-indoline]-2′,4-diones have been synthesized by ketene–imine cycloadditon and evaluated for their antibacterial and antifungal activities.Figure optionsDownload full-size imageDownload as PowerPoint slide