The solid phase of ginkgolide K: Structure and physicochemical properties

•Four solvates of ginkgolide K (forms I–IV) and one solvate-free (V) have been reported for the first time.•X-ray diffraction, thermal analysis and IR spectra were used to characterize the solid phases of ginkgolide K.•The crystal structure of forms I–IV were analyzed and discussed in detail.

Four solvates of ginkgolide K with dimethyl sulfoxide(I), water molecule(II), acetone-isopropyl alcohol(III), methanol-ethanol(IV) and one solvate-free (V) have been described in this work. And the solid-state techniques such as X-ray diffraction, thermal analysis and Fourier transform infrared spectroscopy were used for characterization of the solid phases. The single crystal structures of ginkgolide K solvates (I–IV) have been determined. Ginkgolide K shows strong inflexibility and solvents being incorporated in the crystal structure results in it forming polymorphs via the diverse hydrogen bond interactions.