Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1401445 | Journal of Molecular Structure | 2016 | 13 Pages |
Abstract
The metal complexes of cefepime with Cr (III), Mn (II), Fe (III), Co (II), Cu (II), Zn (II), Cd (II), Hg (II) and mixed metals (Fe, Ni) or (Cu, Fe) were synthesized, the suggested structures of the complexes are based on the results of the elemental analysis, infrared, UV-visible, mass and HNMR spectra, effective magnetic moment as well as the thermal analysis (DTA, TGA & DSC) and characterized by energy dispersive x-ray (EDX) and scanning electron microscopy (SEM). The results obtained suggested that cefepime reacted with metal ions as bidentate ligand through the nitrogen of the β-lactone thiozolidine ring and carboxylate ion forming a five membered ring. The kinetic thermodynamic parameters were estimated from the DTA curves.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mamdouh S. Masoud, Alaa E. Ali, Doaa A. Ghareeb, Nessma M. Nasr,