Article ID Journal Published Year Pages File Type
1402198 Journal of Molecular Structure 2015 6 Pages PDF
Abstract

•Colon cancer detection by THz-TDS.•Paraffin-embedded samples.•Sample cancer affected tissue zones, low transmittance.•High absorption coefficient and refractive index for affected tissue.•Dehydration of bio-tissues lead t low contrast.

In this work, samples of non-neoplastic and adenocarcinoma-affected human colon tissue samples were analyzed using multipoint transmission time-domain THz spectroscopy (THz-TDS) to sort out the contrast-contributing factors other than water, the main contrast mechanism factor in in-vivo or in freshly excised bio-tissue. Solving the electromagnetic inverse problem through THz-TDS and, analyzing the transmittance spectra that yielded the frequency-dependent absorption coefficient α and refractive index n of non-neoplastic and neoplastic tissues, we show that it is possible to distinguish between non-neoplastic and neoplastic regions in paraffin-embedded dehydrated. Results and discussion are presented.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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