| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1403290 | Journal of Molecular Structure | 2013 | 7 Pages |
Abstract
This work describes the synthesis of 2-iodo-3,4,5-trimethoxybenzoic acid. The combination of iodine and silver trifluoroacetate (AgTFA) reagents was used successfully for the iodination of 3,4,5-trimetoxybenzoic acid. To improve the efficiency of the synthetic process a significant modification on the experimental design was also performed. The main structural features of the obtained aryl iodide were investigated by a single crystal X-ray diffraction analysis, FTIR, 1H and 13C NMR spectroscopy.
► The main advantage of the applied synthetic procedure is its operational simplicity. ► The experimental setup allows controlled addition of I2 using less organic solvent. ► The structure of the reaction product has been identified.
Related Topics
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Authors
Iliyan N. Kolev, Svetlana P. Petrova, Rositsa P. Nikolova, Louiza T. Dimowa, Boris L. Shivachev,