| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1403838 | Journal of Molecular Structure | 2011 | 7 Pages |
Two binuclear vanadium–catecholate complexes [Et3NH]2[VVO2(μ-cat)]2(1) and [Et3NH]2[VVO2(μ-N-2,3-D)]2(2) (cat = catechol, N-2,3-D = naphthalene-2,3-diol) have been synthesized and characterized by X-ray diffraction, IR, UV–vis spectroscopy and cyclic voltammetry (CV). X-ray analysis reveals that the structures of complexes 1 and 2 are both in the anion form of V2VO4(L)22-. Et3N works as counter-ions and connects the main frame by hydrogen bonding. The electrochemical behavior of the two complexes is studied in comparison to that of the free ligands and the two complexes display different redox potentials. Pharmaceutical screenings of complexes 1 and 2 have been made against two representative cancer cell-lines A-549 (lung cancer) and Bel-7402 (liver cancer) by MTT assay. The inhibition of cell proliferation was determined 72 h after cells were exposed to the tested compounds at a concentration of 5 μg/mL. Complex 1 exhibits well inhibition ratio against both two cell-lines (76.28% and 75.94%), while 2 displays positive and negative effect (65.36% and −68.82%) respectively. In association with X-ray and electrochemistry, a preliminary analysis about the possible inhibitory mechanism is provided.
► Two binuclear vanadium–catecholate complexes were synthesized and characterized. ► Anti-cancer effects of the two complexes were evaluated by MTT assay and compared. ► Possible anti-cancer mechanisms were analyzed according to X-ray and CV results.
